Genki Desu is among those Japanese expressions that are utilized a lot and don't really indicate what you believe they indicate. You can use it as a greeting: O Genki Desu Ka? (お元気ですか - how are you), or to state you're feeling fine (元気です - Genki Desu). The word Genki also implies 'energy' or 'vitality'. I am not a professional, in fact, there's a lot Japanese I can actually speak (embarassment on me), but Genki Desu is among my favourites. Possibly simply due to the fact that it sounds so nice!
Genki Desu is a cartoon/kid's font. It is pleased, kawaii and loaded with Genki, so use it for any design that needs a little bit of cute.
In the word of the fantastic Yoda: 'May the Genki be with you!'.
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